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Search icon An illustration of a magnifying glass. In an acute asthmatic attack an increasing PCO 2 , even though it may be within the reference interval, is a very sinister development as it usually indicates a serious deterioration in the patient's condition due to exhaustion. For this reason, instead of a formal water deprivation test, an alternative approach is to restrict fluid overnight 8 pm�10 am and measure urine osmolality the following morning in an early morning spot urine.
